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Regarding treatment strategies, it is suggested that the marked decrease in GPx1 expression may be the major mechanism of tumor sensitization to anthracyclines [93] and that GPx1 can partially inhibit doxorubicin-induced cell death-related signaling in breast cancer by interfering with the activation of the sphingomyelin-ceramide pathway [85]

She wrote that on the basis of available epidemiological evidence, the amount of DHA required for a protective benefit would be one fish meal a week, 0.18g/d of DHA, (based on one 3-oz serving of cooked Atlantic salmon, for example)....] note from Jules Levin: I think other factors besides fish intake may effect DHA levels so for some individuals more than 1 fish meal a week may be required

While your body produces it on its own, levels can decline with age